Preview

Biomedical Photonics

Расширенный поиск

Актинический кератоз (обзор литературы)

https://doi.org/10.24931/2413-9432-2022-11-1-37-48

Полный текст:

Аннотация

Актинический кератоз (АК) рассматривается как предраковое состояние, ассоциированное с повышенным, в случаях отсутствия лечения до 20%, риском развития плоскоклеточного рака кожи. По мере дальнейшего развития технологий ранней диагностики онкологических заболеваний, в том числе и рака кожи, увеличения продолжительности жизни людей и популяризации путешествий в экзотические страны, число случаев АК среди населения будет возрастать. В этой связи информирование медицинского сообщества о причинах и патогенезе заболевания, разнообразии клинической картины АК, методах неинвазивной диагностики и лечения представляется важной медико-социальной задачей. Каждый из диагностических и терапевтических методов имеет свои преимущества и недостатки, поэтому, руководствуясь данными доказательной медицины, важно персонифицировать подходы к диагностике и лечению для каждого конкретного пациента. Более того, после лечения АК часто возникают рецидивы, которые являются следствием недостаточной диагностики и выработки неправильной тактики лечения. В обзорной статье приводятся клиническая картина АК, сравнительная характеристика диагностических и лечебных методов с позиций эффективности и безопасности применения у пациентов с АК.

Об авторах

Е. В. Филоненко
«Московский научно-исследовательский онкологический институт им. П.А. Герцена – филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Министерства здравоохранения Российской Федерации
Россия

Москва



С. С. Окушко
«Государственный научный центр лазерной медицины им. О.К. Скобелкина ФМБА»
Россия

Москва



Список литературы

1. Heppt M.V., Schlager G., Berking С. et al. Fitzpatricks dermatology in general medicine // McGraw-Hill. – 2019.

2. Schmitt J.V., Miot H.A. Actinic keratosis: a clinical and epidemiological revision // An Bras Dermatol. – 2012. – Vol. 87. – P. 425-34.

3. Ruini C. et al. In-Vivo LC-OCT Evaluation of the Downward Proliferation Pattern of Keratinocytes in Actinic Keratosis in Comparison with Histology: First Impressions from a Pilot Study // Cancers. – 2021. – Vol. 13. – P. 2856.

4. Reinehr CPH, Bakos RM. Actinic keratoses: review of clinical, dermoscopic, and therapeutic aspects // An Bras Dermatol. – 2019. – Vol. 94. – P. 637-657.

5. Elder D.E., Massi D., Scolyer R., Willemze R. WHO Classification of Skin Tumours // World Health Organization. – 2018. – Vol. 4. – P. 469-500.

6. Ciazynska M. et al. Ultraviolet Radiation and Chronic Inflammation—Molecules and Mechanisms Involved in Skin Carcinogenesis: A Narrative Review // Life. – 2021. – Vol. 11. – P. 326.

7. Dodds A., Chia A., Shumack S. Actinic keratosis: rationale and management // Dermatol Ther (Heidelb). – 2014. – Vol. 4. – P. 11-31.

8. Wermker K., Kluwig J., Schipmann S., Klein M., Schulze H.J., Hallermann C: Prediction score for lymph node metastasis from cutaneous squamous cell carcinoma of the external ear // Eur J Surg Oncol. – 2015. – Vol. 41. – P. 128-35.

9. Jansen et al. A study into the cost effectiveness of four treatments for actinic keratosis in the head and neck area // Br J Dermatol. – 2020. – Vol. 183. – P. 738-744

10. Lehmann M. et al. The extent of public awareness, understanding and use of the Global Solar UV index as a worldwide health promotion instrument to improve sun protection: protocol for a systematic review // BMJ Open. – 2019. – Vol. 9. – P. е028-092.

11. Каприн А. Д., Старинский В. В., Петрова Г. В. (ред.) Состояние онкологической помощи населению России в 2019 году. – 2020. – P. 239.

12. Casari A., Chester J., Pellacani G. Actinic keratosis and non-invasive diagnostic techniques: an update // Biomedicines. – 2018. – Vol. 6. – P. 8.

13. Figueras FMT. From actinic keratosis to squamous cell carcinoma: pathophysiology revisited // J Eur Acad Dermatol Veneorol. – 2017. – Vol. 2. – P. 5-7.

14. Madani SMD et al. Ten-year Follow-up of Persons With Sun Damaged Skin Associated With Subsequent Development of Cutaneous Squamous Cell Carcinoma // JAMA Dermatol. – 2021. – Vol. 157(5). – P. 559-565.

15. Rosen T., Lebwohl M.G. Prevalence and awareness of actinic keratosis: barriers and opportunities // J Am Acad Dermatol. – 2013. – Vol. 68. – P. S2-9.

16. Zalaudek I., Giacomel J., Argenziano G., Hofmann-Wellenhof R., Micantonio T., Di Stefani A., et al. Dermoscopy of facial nonpig mented actinic keratosis // Br J Dermatol. – 2006. – Vol. 155. – P. 951-956.

17. Ceilley R.I., Jorizzo J.L. Current issues in the manage-ment of actinic keratosis // J Am Acad Dermatol. – 2013. – Vol. 68. – P. S28-38.

18. Rossi R., Mori M., Lotti T. Actinic keratosis // Int J Dermatol. – 2007. – Vol. 46. – P. 895-904.

19. De Berker D., McGregor J.M., Mohd Mustapa M.F., Exton L.S., Hughes B.R. British Association of Dermatologists’ guidelines for thecare of patients with actinic keratosis 2017 // Br J Dermatol. – 2017. – Vol. 176. – P. 20-43.

20. Bakos L., Mastroeni S., Bonamigo R.R., Melchi F., Pasquini P., Fortes C. A melanoma risk score in a Brazilian population // An Bras Dermatol. – 2013. – Vol. 88. – P. 226-232.

21. Krawtchenko N., Roewert-Huber J., Ulrich M., Mann I., Sterry W., Stockfleth E. A randomised study of topical 5% imiquimod vs. topical 5-fluorouracil vs. cryosurgery in immunocompetent patients with actinic keratoses: a comparison of clinical and histological outcomes including 1-year follow-up // Br J Dermatol. – 2007. – Vol. 157. – P. 34-40.

22. Gupta A.K., Paquet M., Villanueva E., Brintnell W. Interventions for actinic keratosis // Cochrane Skin Group. – 2012. – Vol.12. – P. CD004415.

23. Heppt M.V., Steeb T., Leiter U., Berking C. Efficacy of photodynamic therapy combined with topical interventions for the treatment of actinic keratosis: a meta-analysis // J Eur Acad Dermatol Venereol. – 2019. – Vol. 33. – P. 863-873.

24. Steeb T., Schlager J.G., Kohl C., Ruzicka T., Heppt M.V., Berking C. Laserassisted photodynamic therapy for actinic keratosis: a systematic review and meta-analysis // J Am Acad Dermatol. – 2019. – Vol. 80. – P. 947-956.

25. Werner R.N., Jacobs A., Rosumeck S., Erdmann R., Sporbeck B., Nast A. Methods and Results Report - evidence and consensus based (S3) Guidelines for the Treatment of Actinic Keratosis International League of Dermatological Societies in cooperation with the European Dermatology Forum // J Eur Acad Dermatol Venereol. – 2015. – Vol. 29. – P. e1-66.

26. Thai K.E., Fergin P., Freeman M., Vinciullo C., Francis D., Spelman L. et al. A prospective study of the use of cryosurgery for the treatment of actinic keratosis // Int J Dermatol. – 2004. – Vol. 43. – P. 687-692.

27. Soleymani T., Abrouk M., Kelly K.M. An analysis of laser therapy for the treatment of nonmelanoma skin cancer // Dermatol Surg. – 2017. – Vol. 43. – P. 615-624.

28. Guimarães C.Z., Miot H.A., Bagatin E. Five percent 5-fluorouracilin a cream or for superficial peels in the treatment of advanced photoaging of the forearms: a randomized comparative study // Dermatol Surg. – 2014. – Vol. 40. – P. 610-617.

29. Loven K., Stein L., Furst K., Levy S. Evaluation of the efficacy and tolerability of 0.5% fluorouracil cream and 5% fluorouracil cream applied to each side of the face in patients with actinic keratosis // Clin Ther. – 2002. – Vol. 24. – P. 990-1000.

30. Swanson N., Abramovits W., Berman B., Kulp J., Rigel D.S., Levy S. Imiquimod 2.5% and 3.75% for the treatment of actinic keratoses: results of two placebo-controlled studies of daily application to the face and balding scalp for two-week cycles // J Am Acad Dermatol. – 2010. – Vol. 62. – P. 582-590.

31. Martin G., Swanson N. Clinical findings using ingenol mebutate gel to treat actinic keratosis // J Am Acad Dermatol. – 2013. – Vol. 68. – P. S39-48.

32. Ulrich M., Pellacani G., Ferrandiz C., Lear J.T. Evidence for field cancerization treatment of actinic keratoses with topical diclofenac in hyaluronic acid // Eur J Dermatol. – 2014. – Vol. 24. – P. 158-167.

33. Vignion-Dewalle A.S., Baert G., Thecua E., Lecomte F., Vicentini C., Abi-Rached H. et al. Comparison of 10 efficient protocols for photodynamic therapy of actinic keratosis: how relevant are effective light dose and local damage in predicting the complete response rate at 3 months // Lasers Surg Med. – 2018. – Vol. 50. – P. 576-589.

34. Wan M.T., Lin J. Current evidence and applications of photodynamic therapy in dermatology // Clin Cosmet Investig Dermatol. – 2014. – Vol. 7. – P. 145-163.

35. Issa M.C., Manela-Azulay M. Photodynamic therapy: a review of the literature and image documentation // An Bras Dermatol. – 2010. – Vol. 85. – P. 501-511.

36. Bakos R.M., Bakos L., Ferlin E., Cestari T., Orlandini T., Rezende R. et al. Terapêutica fotodinâmica com ácido delta-aminolevulínico em neoplasias queratinocíticas superficiais // An Bras Dermatol. – 2003. – Vol. 78. – P. 197-207.

37. Rkein A.M., Ozog D.M. Photodynamic therapy // Dermatol Clin. – 2014. – Vol. 32. – P. 415-425.

38. Torezan L., Grinblat B., Haedersdal M., Valente N., Festa-Neto C., Szeimies R.M. A randomized split-scalp study comparing calcipotriol-assisted methyl aminolaevulinate photodynamic therapy (MAL-photodynamic therapy (PDT)) with conventional MAL-photodynamic therapy (PDT) for the treatment of actinic keratosis // Br J Dermatol. – 2018. – Vol. 179. – P. 829-835.

39. Dianzani C., Conforti C., Giuffrida R., Corneli P., Di Meo N., Farinazzo E., Moret A., Magaton R.G., Zalaudek I. Current therapies for actinic keratosis // Int J Dermatol. – 2020. – Vol. 59(6). – P. 677-684.

40. Gutiérrez G-R.C., Pellegrini C., Piccioni A. et al. Single versus two-treatment schedule of methyl aminolevulinate daylight photodynamic therapy for actinic keratosis of the face and scalp: an intra-patient randomized trial // Photodiagnosis Photodyn Ther. – 2019. – Vol. 27. – P. 100-104.

41. Brian Jiang S.I., Kempers S., Rich P. et al. A randomized, vehicle controlled phase 3 study of aminolevulinic acid photodynamic therapy for the treatment of actinic keratoses on the upper extremities // Dermatol Surg. – 2019. – Vol. 45(7). – P. 890-897.

42. Ozog D.M., Rkein A.M., Fabi S.G. et al. Photodynamic therapy: a clinical consensus guide // Dermatol Surg. – 2016. – Vol. 42(7). – P. 804-827.

43. American Accademy of Dermatology // Clinical guidelines. Available at. – 2022.

44. Werner R.N., Stockfleth E., Connolly S.M. et al. Evidence- and consensus-based (S3) Guidelines for the Treatment of Actinic Keratosis – International League of Dermatological Societies in cooperation with the European Dermatology Forum – short version // J Eur Acad Dermatol Venereol. – 2015. – Vol. 29(11). – P. 2069-2079.

45. Berker D., McGregor J.M., Mohd Mustapa M.F. et al. British Association of Dermatologists’ guidelines for the care of patients with actinic keratosis 2017 // Br J Dermatol. – 2017. – Vol. 176(1). – P. 20-43.

46. Morton CA, Szeimies R-M, Basset-Seguin N. et al. European Dermatology Forum guidelines on topical photodynamic therapy 2019 Part 1: treatment delivery and established indications – actinic keratoses, Bowen’s disease and basal cell carcinomas // J Eur Acad Dermatol Venereol. – 2019. – Vol. 33(12). – P. 2225- 2238.

47. Patel G., Armstrong A.W., Eisen D.B. Efficacy of photodynamic therapy vs other interventions in randomized clinical trials for the treatment of actinic keratoses: a systematic review and meta analysis // JAMA Dermatol. – 2014. – Vol. 150(12). – P. 1281-1288.

48. Nestor M., Gold M.H., Kauvar A., Taub A.F., Geronemus R.G., Ritvo E. The use of photodynamic therapy in dermatology: results of a consensus conference // J Drugs Dermatol. – 2006. – Vol. 5. – P. 140-154.

49. Wollina U., Gaber B., Koch A. Photodynamic treatment with nanoemulsified 5-aminolevulinic acid and narrow band red light for field cancerization due to occupational exposure to ultraviolet light irradiation // Georgian Med News. – 2018. – Vol. 274. – P. 138- 143.

50. Genovese G., Fai D., Fai C. et al. Daylight methylaminolevulinate photodynamic therapy versus ingenol mebutate for the treatment of actinic keratoses: an intraindividual comparative analysis // Dermatol Ther. – 2016. – Vol. 29(3). – P. 191-196.

51. Holzer G., Pinkowicz A., Radakovic S. et al. Randomized controlled trial comparing 35% trichloroacetic acid peel and 5-aminolaevulinic acid photodynamic therapy for treating multiple actinic keratosis // Br J Dermatol. – 2017. – Vol. 176(5). – P. 1155-1161.

52. Perrett C.M., McGregor J.M., Warwick J. et al. Treatment of post transplant premalignant skin disease: a randomized intrapatient comparative study of 5-fluorouracil cream and topical photodynamic therapy // Br J Dermatol. – 2007. – Vol. 156(2). – P. 320-328.

53. Jansen M.H.E, Kessels JP H.M., Nelemans P.J. et al. Randomized trial of four treatment approaches for actinic keratosis // N Engl J Med. – 2019. – Vol. 380(10). – P. 935-946.

54. Moy L.S., Frost D., Moy S. Photodynamic therapy for photodamage, actinic keratosis, and acne in the cosmetic practice // Facial Plast Surg Clin North Am. – 2020. – Vol. 28(1). – P. 135-148.

55. Cleveland Clinic. Photodynamic therapy (PDT): risks/venefits // Available at. – 2021.

56. Chaves Y.N., Torezan L.A., Niwa A.B.M., Sanches Junior J.A., Festa Neto C. Pain in photodynamic therapy: mechanism of action and management strategies // An Bras Dermatol. – 2012. – Vol. 87. – P. 521- 527.

57. Kaviani A., Ataie-Fashtami L., Fateh M., Sheikhbahaee N., Ghodsi M., Zand N. et al. Photodynamic therapy of head and neck basal cell carcinoma according to different clinicopathologic features // Lasers Surg Med. – 2005. – Vol. 36. – P. 377-382.

58. Galvão LE.G., Goncalves H.S., Botelho K.P., Caldas J.C. Daylight photodynamic therapy --- experience and safety in treatment of actinic keratoses of the face and scalp in low latitude and high brightness region // An Bras Dermatol. – 2017. – Vol. 92. – P. 142- 144.

59. See J.-A., Shumack S., Murrell D.F., Rubel D.M., Fernández-Pe˜nasP., Salmon R., et al. Consensus recommendations on the use of daylight photodynamic therapy with methyl aminolevulinate cream for actinic keratoses in Australia: daylight photodynamic therapy (PDT) consensus recommendations // Australas J Dermatol. – 2016. – Vol. 57. – P. 167-174.

60. Sotiriou E., Evangelou G., Papadavid E., Apalla Z., Vrani F., Vakirlis E. et al. Conventional vs. daylight photodynamic therapy for patients with actinic keratosis on face and scalp: 12-monthfollow up results of a randomized, intra-individual comparative analysis // J Eur Acad Dermatol Venereol. – 2018. – Vol. 32. – P. 595-600.

61. Rubel D.M., Spelman L., Murrell D.F., See J.A., Hewitt D., Foley P., Bosc C., Kerob D., Kerrouche N., Wulf H.C. et al: Daylight photodynamic therapy with methyl aminolevulinate cream as a convenient, similarly effective, nearly painless alternative to conventional photodynamic therapy in actinic keratosis treatment: a randomized controlled trial // Br J Dermatol. – 2014. – Vol. 171(5). – P. 1164-1171.

62. Maytin E.V., Anand S., Riha M. et al. 5-Fluorouracil enhances protoporphyrin IX accumulation and lesion clearance during photodynamic therapy of actinic keratoses: a mechanism-based clinical trial // Clin Cancer Res. – 2018. – Vol. 24(13). – P. 3026-3035.

63. Seo J.W., Song K.H. Topical calcipotriol before ablative fractional laser-assisted photodynamic therapy enhances treatment outcomes for actinic keratosis in Fitzpatrick grades III-V skin: a prospective randomized clinical trial // J Am Acad Dermatol. – 2018. – Vol. 78(4). – P. 795-797.

64. Willey A., Mehta S., Lee P.K. Reduction in the incidence of squamous cell carcinoma in solid organ transplant recipients treated with cyclic photodynamic therapy // Dermatol Surg. – 2010. – Vol. 36(5). – P. 652-658.

65. Togsverd-Bo K., Omland S.H., Wulf H.C. et al. Primary prevention of skin dysplasia in renal transplant recipients with photodynamic therapy: a randomized controlled trial // Am J Transplant. – 2015. – Vol. 15(11). – P. 2986-2990.

66. Bernad I., Aguado L., Núñez-Córdoba J.M., Redondo P. Daylight photodynamic therapy for prevention of new actinic keratosis and keratinocyte carcinomas in organ transplants. A cryotherapy controlled randomized clinical trial // J Eur Acad Dermatol Venereol. – 2020. – Vol. 34(7). – P. 1464-1470.

67. Liew Y.C.C., De Souza N.A., Sultana R.G., Oh C.C. Photodynamic therapy for the prevention and treatment of actinic keratosis/ squamous cell carcinoma in solid organ transplant recipients: a systematic review and meta-analysis // J Eur Acad Dermatol Venereol. – 2020. – Vol. 34(2). – P. 251-259.

68. Gupta A.K., Paquet M. Network meta-analysis of the outcome «participant complete clearance» in nonimmune suppressed participants of eight interventions for actinic kerato-sis: a follow up on a Cochrane review // Br J Dermatol. – 2013. – Vol. 169. – P. 250-259.

69. Szeimies R.M. A network meta-analysis of the relative efficacy of treatments for actinic keratosis of the face or scalp in Europe // J Eur Acad Dermatol Venereol. – 2016. – Vol. 30. – P. 1619-1620.

70. Lerche C.M., Heerfordt I.M., Heydenreich J., Wulf H.C. Alternatives to Outdoor Daylight Illumination for Photodynamic Therapy-Use of Greenhouses and Artificial Light Sources // Int J Mol Sci. – 2016. – Vol. 17(3) – P. 309.

71. Lecomte F., Vignion-Dewalle A.S., Vicentini C., Thecua E., Deleporte P., Duhamel A., Mordon S., Mortier L. A phase II study evaluating the non-inferiority of a photodynamic therapy protocol involving the Flexitheralight device compared to the conventional protocol (the FLEXITHERALIGHT study) // JMIR research protocols. – 2018.


Рецензия

Для цитирования:


Филоненко Е.В., Окушко С.С. Актинический кератоз (обзор литературы). Biomedical Photonics. 2022;11(1):37-48. https://doi.org/10.24931/2413-9432-2022-11-1-37-48

For citation:


Filonenko E.V., Okushko S.S. Actinic keratosis (review of literature). Biomedical Photonics. 2022;11(1):37-48. https://doi.org/10.24931/2413-9432-2022-11-1-37-48

Просмотров: 232


Creative Commons License
Контент доступен под лицензией Creative Commons Attribution 4.0 License.


ISSN 2413-9432 (Print)