Preview

Biomedical Photonics

Advanced search

Modern aspects of photodynamic therapy of basal cell skin cancer

https://doi.org/10.24931/2413-9432-2022-11-3-35-39

Abstract

Photodynamic therapy (PDT) is one of the most effective treatments for basal cell skin cancer (BCC). As the incidence rate of BCC is increasing worldwide, interest in developing new methods for diagnosing and treating this disease, taking into account long-term cosmetic results, is growing. The review article presents the results of domestic and foreign studies on the treatment of BCC with PDT. The presented results of studies from various domestic and foreign clinics indicate the high efficiency of independent PDT and a combination of PDT with other treatment methods. PDT is proposed to be used in combination with surgical methods and radiation therapy, immunomodulating and chemotherapeutic agents, and inhibitors of molecules involved in the carcinogenic process. These new strategies open the way to increasing the effectiveness of treatment and prevention of BCC. Moreover, in all studies, the safety of this non-invasive treatment, a low level of adverse reactions during therapy, good tolerance for the patient and excellent cosmetic treatment results are noted. The guidelines currently being developed in Europe and the United States provide consistent expert advice that reflects current published evidence of treatment outcomes for BCC using PDT. Moreover, the recommendations emphasize that the treatment plan for patients with “difficult to treat” BCC should be discussed at an interdisciplinary oncological council.

About the Authors

I. V. Reshetov
Sechenov First Moscow State Medical University, FSBF FRCC of the FMBA, Moscow Witte University
Russian Federation


S. V. Korenev
Immanuel Kant Baltic Federal University
Russian Federation


Yu. S. Romanko
Sechenov First Moscow State Medical University, FSBF FRCC of the FMBA
Russian Federation


References

1. Baykalova O.I., Belyaev A.M., Prokhorov G.G., Radzhabova Z.A. Treatment of squamous cell carcinoma of the skin with the use og cryogenic technologies, Siberian journal of oncology, 2020, vol. 19, no. 6, pp. 99–105. (In Russian).

2. Cameron M.C., Lee E., Hibler B.P., Barker C., Mori S., Cordova M., Nehal K.S., Rossi A.M. Basal cell carcinoma: Epidemiology; pathophysiology; clinical and histological subtypes; and disease associations, J Am Acad Dermatol, 2019, vol. 80(2), pp. 303-317.

3. Filonenko E.V., Serova L.G. Photodynamic therapy in clinical practice, Biomedical Photonics, 2016, vol. 5, no. 2, pp. 26–37 (in Russian).

4. Belova I.A. Risk of local relapse, metastases, new primary tumors, and cosmetic defects in patients with malignant skin tumors. German experience of their prevention, Head and neck. Russian Journal, 2013, no. 1, pp. 25–39 (in Russian).

5. Belova I.A. Methods of microscopically controlled surgery (review), Head and neck. Russian Journal, 2013, no. 3, pp. 22–34 (in Russian).

6. Polyakov P.Y., Oltarzhevskaya N.D., Bychenkov O.A., Korovina M.A. Radiotherapy of skin carcinoma with directed application of metronidazol as a radiosensitizing agent, Head and neck. Russian Journal, 2013, no. 1, pp. 14–18 (in Russian).

7. Breuninger H., Belova I. Instruction for conducting microscopically controlled surgery and threedimensional hystology for removal of malignant skin lesions, Head and neck. Russian Journal, 2017, no. 4, pp. 62–72 (in Russian).

8. Pustynskiy I.N., Paches A.I., Tkachev S.I., Kropotov M.A., Alieva S.B., Yagubov A.S., Bazhutova G.A., Slanina S.V. Cryoradiotherapy for patients with locally advanced buccal skin cancer, Siberian Journal of Oncology, 2013, no. 6, pp. 5–8 (in Russian).

9. Prokhorov G.G., Galunova Т.Yu., Radzhabova Z.А., Madagov А.S., Kotov М.А., Nazhmudinov R.А., Rakitina D.А., Artemiev S.S. Microflora of infiltrative-ulcerative form of basal cell skin cancer against the background of cryogenic treatment, Vopr Onkol, 2017, vol. 63, no. 3, pp. 486-489 (in Russian).

10. Molochkov A.V., Rumyantsev S.A., Khlebnikova A.N. Enhancement of interferon treatment for large basaliomas, Almanac of Clinical Medicine, 2017, vol. 45, no. 4, pp. 314-320 (in Russian).

11. Pustynskiy I.N., Tabolinovskaya T.D., Tkachev S.I., Alieva S.B., Azizian R.I., Kiva E.V., Egorova A.V., Peterson S.B. The treatment of patients with locally-advanced recurrent skin cancer of the face by cryo-radiotherapy, Siberian Journal of Oncology, 2017, vol. 16, no. 6, pp. 67–72 (in Russian).

12. Shaikhaliev A.I., Petruk P.S., Arazashvili L.D., Polyakov K.A., Cherkesov I.V., Kolobovnikova A.I. New approaches in basal cell carcinoma treatment. Case report, Head and neck. Russian Journal, 2018, no. 2, pp. 45–49 (in Russian).

13. Yuzhakov V.V., Burmistrova N.V., Fomina N.K., Bandurko L.N., Sevanjkaeva L.E., Starovoytova A.V., Yakovleva N.D., Tsyganova M.G., Ingelj I.E., Ostroverkhov P.V., Kaplan M.A., Grin M.A., Mazhuga A.G., Mironov A.F., Galkin V.N., Romanko Yu.S. Morphofunctional characteristics of rat sarcoma M-1 after photodynamic therapy with the bacteriochlorophyll a derivative, Biomedical Photonics, 2016, vol. 5, no. 4, pp. 4-14 (in Russian).

14. Filonenko E.V. Clinical implementation and scientific development of photodynamic therapy in Russia in 2010-2020. Biomedical Photonics, 2021, Vol. 10(4), pp. 4-22. doi: 10.24931/2413-9432- 2021-9-4-4-22

15. Reshetov I.V., Korenev S.V., Romanko Yu.S. Forms of cell death and targets at photodynamic therapy, Siberian Journal of Oncology, 2022, vol. 21, no. 5, pp. 149–154.

16. Fargnoli M.C., Peris K. Photodynamic therapy for basal cell carcinoma, Future Oncol, 2015, vol. 11(22), pp. 2991-2996.

17. Romanko Y.S., Kaplan M.A., Ivanov S.A., Galkin V.N., Molochkova Y.V., Kuntsevich Z.S., Tretiakova E.I., Sukhova T.E., Molochkov V.A., Molochkov A.V. Efficacy of photodynamic therapy for basal cell carcinoma using photosensitizers of different classes, Vopr Onkol, 2016, vol. 62, no. 3, pp. 447-50 (in Russian).

18. Morton C.A., Szeimies R.M., Basset-Seguin N., Calzavara-Pinton P., Gilaberte Y., Haedersdal M., Hofbauer G.F.L., Hunger R.E., Karrer S., Piaserico S., Ulrich C., Wennberg A.M., Braathen L.R. European Dermatology Forum guidelines on topical photodynamic therapy 2019 Part 1: treatment delivery and established indications – actinic keratoses, Bowen’s disease and basal cell carcinomas, J Eur Acad Dermatol Venereol, 2019, vol. 33(12), pp. 2225-2238.

19. Peris K., Fargnoli M.C., Garbe C., Kaufmann R., Bastholt L., Seguin N.B., Bataille V., Marmol V.D., Dummer R., Harwood C.A., Hauschild A., Höller C., Haedersdal M., Malvehy J., Middleton M.R., Morton C.A., Nagore E., Stratigos A.J., Szeimies R.M., Tagliaferri L., Trakatelli M., Zalaudek I., Eggermont A., Grob J.J.; European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO) and the European Organization for Research and Treatment of Cancer (EORTC). Diagnosis and treatment of basal cell carcinoma: European consensus-based interdisciplinary guidelines, Eur J Cancer, 2019, vol. 118, pp. 10-34.

20. Morton C., Szeimies R.M., Sidoroff A., Wennberg A.M., Basset- Seguin N., Calzavara-Pinton P., Gilaberte Y., Hofbauer G., Hunger R., Karrer S., Lehmann P., Piaserico S., Ulrich C., Braathen L.; European Dermatology Forum. European Dermatology Forum Guidelines on topical photodynamic therapy, Eur J Dermatol, 2015, vol. 25(4), pp. 296-311.

21. Ozog D.M., Rkein A.M., Fabi S.G., Gold M.H., Goldman M.P., Lowe N.J., Martin G.M., Munavalli G.S. Photodynamic Therapy: A Clinical Consensus Guide therapy, Dermatol Surg, 2016., vol. 42(7), pp. 804-827.

22. Savoia P., Deboli T., Previgliano A., Broganelli P. Usefulness of Photodynamic Therapy as a Possible Therapeutic Alternative in the Treatment of Basal Cell Carcinoma, Int J Mol Sci, 2015, vol. 16(10), pp. 23300-23317.

23. Morton C.A. A synthesis of the world’s guidelines on photodynamic therapy for non-melanoma skin cancer, Eur J Cancer, 2018, vol. 153(6), pp. 783-792.

24. Blanco K.C., Inada N.M., Silva A.P., Stringasci M.D., Buzzá H.H., Ramirez D.P., Sálvio A.G., Moriyama L.T., Kurachi C., Bagnato V.S. A Multicenter Clinical Study of Expected and Unexpected Side Reactions During and After Skin Cancer Treatment by Photodynamic Therapy, Skinmed, 2017, vol. 15(2), pp. 113- 118.

25. Filonenko E.V., Grigoryevykh N.I., Ivanova-Radkevich V.I. Photodynamic therapy of a patient with basal cell skin cancer of the ear stage T3N0M0 (clinical case), Biomedical Photonics, 2021, vol. 10, no. 4, pp. 68–70 (in Russian).

26. Paoli J., Gyllencreutz J.D., Fougelberg J., Backman E.J., Modin M., Polesie S., Zaar O. Nonsurgical Options for the Treatment of Basal Cell Carcinoma, Dermatol Pract Concept, 2019, vol. 9(2), pp. 75-81.

27. Kaplan M.A., Romanko Y.S. Photodynamic therapy as a new radical treatment for patients with recurrent tumors, Vopr Onkol, 2000, vol. 46, no. 2, p. 238 (in Russian).

28. Lucena S.R., Salazar N., Gracia-Cazaña T., Zamarrón A., González S., Juarranz Á., Gilaberte Y. Combined Treatments with Photodynamic Therapy for Non-Melanoma Skin Cancer, Int J Mol Sci, 2015, vol. 16(10), pp. 25912-25933.

29. Ferrara F., Lacava R., Barisani A., Messori S., Patrizi A., Bardazzi F., Vaccari S. Combined CO2 laser and photodynamic therapy enhances the efficacy of treatment of basal cell carcinomas, J Dtsch Dermatol Ges, 2019, vol. 17(12), pp. 1251-1256.

30. Li X., Tan L., Kou H., Zhang J., Wang Y., Li G., Lu Y. Ocular preservation through limited tumor excision combined with ALA-PDT in patients with periocular basal cell carcinoma, Photodiagnosis Photodyn Ther, 2019, vol. 27, pp. 291-294.

31. Zeitouni N.C., Sunar U., Rohrbach D.J., Paquette A.D., Bellnier D.A., Shi Y., Wilding G., Foster T.H., Henderson B.W. A prospective study of pain control by a 2-step irradiance schedule during topical photodynamic therapy of nonmelanoma skin cancer, Dermatol Surg., 2014, vol. 40(12), pp. 1390-1394.


Review

For citations:


Reshetov I.V., Korenev S.V., Romanko Yu.S. Modern aspects of photodynamic therapy of basal cell skin cancer. Biomedical Photonics. 2022;11(3):35-39. https://doi.org/10.24931/2413-9432-2022-11-3-35-39

Views: 558


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2413-9432 (Print)