The mechanisms of photodynamic action for treating of cancer patients
https://doi.org/10.24931/2413-9432-2015-4-2-9-16
Abstract
Current views on mechanisms of therapeutic effect of photodynamic therapy for treating of cancer patients are represented. The history of formation and development of the method is described. The main requirements for agents used as photosensitizers are listed. Detailed review of main photosensitizers used in clinical practice in Russia and in foreign countries with their chemical structure, main spectral characteristics was performed. Methods of its application, therapeutic dose ranges, indications, specifi c pharmacokinetic properties and side-effects are briefl y outlined. Advantages and disadvantages of the most popular modern photosensitizers, main mechanisms of entry of photosensitizers of different chemical structure into cancer cells are observed. Three main possible component of anti-tumor effect: direct damage of cancer cells, impairment of vascular stroma of tumor and elimination of tumor due to immune cells are shown and closely discussed. Necrosis and apotosis of neovascular net which are main development trends of anti-tumor action for photodynamic therapy are noticed.
About the Authors
A. L. Akopov
Pavlov First Saint-Petersburg State Medical University, Saint-Petersburg
Russian Federation
Russian Federation
N. V. Kazakov
Pavlov First Saint-Petersburg State Medical University, Saint-Petersburg
Russian Federation
Russian Federation
A. A. Rusanov
Pavlov First Saint-Petersburg State Medical University, Saint-Petersburg
Russian Federation
Russian Federation
A. Karlson
Pavlov First Saint-Petersburg State Medical University, Saint-Petersburg
Russian Federation
Russian Federation
References
1. Dougherty T.J., Gomer C.J., Henderson B.W., et al. Photodynamic therapy, J. Natl. Cancer Inst., 1998, Vol. 90, pp. 889–905.
2. Filonenko E. Fluorestsentnaya diagnostika i fotodinamicheskaya terapiya v onkologii (Fluorescence diagnosis and photodynamic therapy in oncology), Nauka v Rossii, 2012, No. 4, pp. 4–9.
3. Allison R.R., Mota H.C., Sibata C.H. Clinical PD/PDT in North America: an historical review, Photodiagnosis Photodyn. Ther., 2004, No. 1, pp. 263–277.
4. Kurohane K, Tominaga A, Sato K, North JR, Namba Y, Oku N. Photodynamic therapy targeted to tumor-induced angiogenic vessels, Cancer Lett., 2001, Vol. 167, pp. 49–56.
5. Lipson R.L., Baldes E.J. Photosensitivity and heat, Arch. Dermatol, 1960, Vol. 82, pp. 517–520.
6. Dougherty T.J., Gomer C.J., Henderson B.W., et al. Photodynamic therapy, J. Natl. Cancer Inst., 1998, Vol. 90, pp. 889–905.
7. Allison R.R., Downie G.H., Cuenca R., Hu X.H., Childs C.J., Sibata C.H. Photosensitizers in clinical PDT, Photodiagnosis Photodyn. Ther., 2004, No. 1, pp. 27–42.
8. Stranadko E.F., Kamenskaya V.N. Fotodinamicheskaya terapiya: naukometricheskoe issledovanie (Photodynamic therapy: a scientometric study), Lazernaya meditsina, 2013, T. 17, No. 2, pp. 44–49.
9. Allison R.R., Moghissi K. Photodynamic Therapy (PDT): PDT Mechanisms, Clin. Endosc., 2013, Vol. 46, pp. 24–29
10. Sokolov V.V., Telegina L.V., Trakhtenberg A.Kh., Kolbanov K.I., Pikin O.V., Frank G.A. Endobronkhial'naya khirurgiya i fotodinamicheskaya terapiya pri pervichno-mnozhestvennom rake legkogo (Endobronchial surgery and fotodynamic therapy for the treatment of multiple primary lung cancer ), Khirurgiya. Zhurnal im. N.I. Pirogova, 2010, No. 7, pp. 28–31.
11. McMahon K.S., Wieman T.J., Moore P.H., Fingar V.H. Effects of photodynamic therapy using mono-L-aspartyl chlorin e6 on vessel constriction, vessel leakage, and tumor response, Cancer Res, 1994, Vol. 54, pp. 5374–5379.
12. Allison R.R., Sibata C.H. Photodiagnosis for cutaneous malignancy: a brief clinical and technical review, Photodiagnosis Photodyn. Ther., 2008, Vol. 5, pp. 247–250.
13. Mang T.S. Lasers and light sources for PDT: past, present and future, Photodiagnosis Photodyn. Ther.,2004, No. 1, pp. 43–48.
14. Brancaleon L., Moseley H. Laser and non-laser light sources for photodynamic therapy, Lasers Med. Sci., 2002, Vol. 17, pp. 173–186.
15. Sibata C.H., Colussi V.C., Oleinick N.L., Kinsella T.J. Photodynamic therapy in oncology, Expert Opin. Pharmacother, 2001, Vol. 2, pp. 917–927.
16. Akopov A., Rusanov A., Gerasin A., Kazakov N., Urtenova M., Chistakov I. Preoperative endobronchial photodynamic therapy improves resectability in initially irresectable (inoperable) locally advanced non-small cell lung cancer // Photodyagnosis and photodynamic therapy, 2014, No. 3, pp. 259–264.
17. Akopov A.L., Rusanov A.A., Chistyakov I.V., Urtenova M.A., Kazakov N.V., Gerasin A.V., Papayan G.V. Primenenie fotodinamicheskoi terapii s tsel'yu umen'sheniya ob"ema rezektsii pri nemelkokletochnom rake legkogo (Application of photodynamic therapy to reduce the amount of resection for non-small cell lung cancer ), Voprosy onkologii, 2013, No. 6, pp. 740–744.
18. Hamblin M.R., Newman E.L. On the mechanism of the tumourlocalising effect in photodynamic therapy, J. Photochem. Photobiol., 1994, Vol. 23, pp. 3–8.
19. Moan J., Berg K. The photodegradation of porphyrins in cells can be used to estimate the lifetime of singlet oxygen, Photochem. Photobiol., 1991, Vol. 53, pp. 549–553.
20. Mroz P., Yaroslavsky A., Kharkwal G.B., Hamblin M.R. Cell death pathways in photodynamic therapy of cancer, Cancers, 2011, Vol. 3, pp. 2516–2539.
21. Boyle R.W., Dolphin D. Structure and biodistribution relationships of photodynamic sensitizers, Photochem. Photobiol., 1996, Vol. 64, pp. 469–485.
22. Hamblin M.R., Rajadhyaksha M., Momma T., Soukos N.S., Hasan T. In vivo fl uorescence imaging of the transport of charged chlorin e6 conjugates in a rat orthotopic prostate tumour, Br. J. Cancer, 1999, Vol. 81, pp. 261–268.
23. Jori G., Reddi E. The role of lipoproteins in the delivery of tumourtargeting photosensitizers, Int. J. Biochem., 1993, Vol. 25, pp. 1369–1375.
24. Castano A.P., Demidova T.N., Hamblin M.R. Mechanisms in photodynamic therapy: part three: photosensitizer pharmacokinetics, biodistribution, tumor localization and modes of tumor destruction, Photodiagnosis Photodyn. Ther., 2005, Vol. 2, pp. 91–106.
25. Castano A.P., Demidova T.N., Hamblin M.R. Mechanisms in photodynamic therapy: part two: cellular signaling, cell metabolism and modes of cell death, Photodiagnosis Photodyn. Ther., 2005, Vol. 2, pp. 1–23.
26. Oleinick N.L., Evans H.H. The photobiology of photodynamic therapy: cellular targets and mechanisms, Radiat. Res., 1998, Vol. 150 (5 Suppl.), pp. 146-156.
27. Moghissi, K., Dixon, K., Thorpe J.A.C. and Stringer M.R. Photodynamic therapy in early central lung cancer: a treatment option for patients ineligible for surgical resection, Thorax, 2007, Vol. 65, pp. 391–395
28. Allison R.R. Future PDT, Photodiagnosis Photodyn. Ther., 2009, Vol. 6, pp. 231–234.
29. Oleinick N.L., Morris R.L., Belichenko I. The role of apoptosis in response to photodynamic therapy: what, where, why, and how, Photochem. Photobiol. Sci., 2002, No. 1, pp. 1–21.
30. Igney F.H., Krammer P.H. Death and anti-death: tumour resistance to apoptosis, Nat. Rev. Cancer, 2002, Vol. 2, pp. 277–288.
31. Ding X., Xu Q., Liu F., et al. Hematoporphyrin monomethyl ether photodynamic damage on HeLa cells by means of reactive oxygen species production and cytosolic free calcium concentration elevation, Cancer Lett., 2004, Vol. 216, pp. 43–54.
32. Henderson B.W., Donovan J.M. Release of prostaglandin E2 from cells by photodynamic treatment in vitro, Cancer Res., 1989, Vol. 49 (24 Pt 1), pp. 6896–6900.
33. Dahle J., Kaalhus O., Moan J., Steen H.B. Cooperative effects of photodynamic treatment of cells in microcolonies, Proc. Natl. Acad. Sci. USA, 1997, Vol. 94, pp. 1773–1778.
34. Henderson B.W., Owczarczak B., Sweeney J., Gessner T. Effects of photodynamic treatment of platelets or endothelial cells in vitro on platelet aggregation, Photochem. Photobiol, 1992, Vol. 56, pp. 513–521.
35. Agarwal M.L., Clay M.E., Harvey E.J., Evans H.H., Antunez A.R., Oleinick N.L. Photodynamic therapy induces rapid cell death by apoptosis in L5178Y mouse lymphoma cells, Cancer Res., 1991, Vol. 51, pp. 5993–5996.
36. Machinskaya E.A., Ivanova-Radkevich V.I. Obzor mekhanizmov selektivnogo nakopleniya fotosensibilizatorov razlichnoi khimicheskoi struktury v opukholevoi tkani (Review of selective accumulation of photosensitizers with different chemical structure in tumor tissue), Fotodinamicheskaya terapiya i fotodiagnostika, 2013, No. 4, pp. 19–23.
37. Chen B., Roskams T., de Witte P.A. Antivascular tumor eradication by hypericin-mediated photodynamic therapy, Photochem. Photobiol., 2002, Vol. 76, pp. 509–513.
38. Kurohane K., Tominaga A., Sato K., North J.R., Namba Y., Oku N. Photodynamic therapy targeted to tumor-induced angiogenic vessels, Cancer Lett., 2001, Vol. 167, pp. 49–56.
39. Chen B., Pogue B.W., Goodwin I.A., et al. Blood fl ow dynamics after photodynamic therapy with verteporfi n in the RIF-1 tumor, Radiat. Res., 2003, Vol. 160, pp. 452–459.
40. Fingar V.H., Wieman T.J., Doak K.W. Role of thromboxane and prostacyclin release on photodynamic therapy-induced tumor destruction, Cancer Res., 1990, Vol. 50, pp. 2599–2603.
41. Krosl G., Korbelik M. Potentiation of photodynamic therapy by immunotherapy: the effect of schizophyllan (SPG), Cancer Lett., 1994, Vol. 84, pp. 43–49.
42. Gollnick S.O., Evans S.S., Baumann H., et al. Role of cytokines in photodynamic therapy-induced local and systemic infl ammation, Br. J. Cancer, 2003, Vol. 88, pp. 1772–1779.
43. Gollnick S.O., Liu X., Owczarczak B., Musser D.A., Henderson B.W. Altered expression of interleukin 6 and interleukin 10 as a result of photodynamic therapy in vivo, Cancer Res., 1997, Vol. 57, pp. 3904–3909.
44. Coutier S., Bezdetnaya L., Marchal S., et al. Foscan (mTHPC) photosensitized macrophage activation: enhancement of phagocytosis, nitric oxide release and tumour necrosis factor-alpha-mediated cytolytic activity, Br. J. Cancer, 1999, Vol. 81, pp. 37–42.
Review
For citations:
Akopov A.L., Kazakov N.V., Rusanov A.A., Karlson A. The mechanisms of photodynamic action for treating of cancer patients. Photodynamic therapy and photodyagnosis. 2015;4(2):9-16. (In Russ.) https://doi.org/10.24931/2413-9432-2015-4-2-9-16
Views:
1761
Email this article 