Spectrophotometric methods and magnifying endoscopy for differential diagnosis of colon lesions
Abstract
The review of recent development in diagnosis of premalignancy and early cancer in colon is represented. The results of several diagnostic methods which are supplemental for convenient colonoscopy, are described. Thus, NBI system (narrow spectrum endoscopy) and FICE combined with system for magnifying endoscopy significantly improve sensitivity and specifity of diagnostic method. However, the serious disadvantage is coloration of intestinal contents into different shades of red, impeding visualization of small structures and lesions. For detection of dysplasia of different degree in patients with colon polyps high levels of sensitivity and specifity were shown in the methods of magnifying and zoom-endoscopy (93.8% and 64.6%, respectively), confocal laser endomicroscopy (81% and 82%, perspectively), and optic coherent tomography (92% and 84%, respectively). The one of the most recent method – immunophotodiagnosis, showed high efficiency for detection of dysplasia and early cancer in patients with colon polyps: the sensitivity was 78.6%, specifity – 100%. Autofluorescence and fluorescence diagnostics with exogenous photosensitizers. The studies showed that autofluorescence diagnosis was valuable method for differential diagnosis of colon tumors (sensitivity was 85%, specifity – 81%).
About the Authors
А. А. Razgivina
The Department of Endoscopy of Russian Medical Academy of Post-Graduate Education, Moscow
Russian Federation
Russian Federation
А. М. Nechipai
The Department of Endoscopy of Russian Medical Academy of Post-Graduate Education, Moscow
Russian Federation
Russian Federation
А. V. Volova
The Department of Endoscopy of Russian Medical Academy of Post-Graduate Education, Moscow
Russian Federation
Russian Federation
S. М. Goryaev
The Department of Endoscopy of Russian Medical Academy of Post-Graduate Education, Moscow
Russian Federation
Russian Federation
А. А. Sokolov
The Department of Endoscopy of Russian Medical Academy of Post-Graduate Education, Moscow
Russian Federation
Russian Federation
References
1. Веселов В.В., Власов С.Б., Кузнецов А.Н. и др. Результаты эндоскопического лечения ранних форм рака толстой кишки // Клиническая эндоскопия. – 2005. – №2. – С. 6–10.
2. Мартынюк В.В. Рак толстой кишки (заболеваемость, смертность, факторы риска, скрининг). / Практическая онкология: избранные лекции. – СПб.: 2004. – С.151–161.
3. Raju G.S., Pasricha P.J. Flat and depressed colorectal neoplasia in the Western Hempshire. / In: Colonoscopy principles and practice. J.D.Waye, D.K. Rex, C.B. Williams eds. – USA: Blackwell Publishing, 2003. – P. 487–500.
4. Winawer S.J. The achievements, impact, and future of the National Polyp Study // Gastrointest Endosc. – 2006. – Vol.64, №6. – P. 975–978.
5. Нешитов С.П. Лечение ворсинчатых аденом дистальных отделов толстой кишки // Хирургия. – 2001. – № 7. – С. 30–33.
6. Jichlinski P., Mizeret J., Forrer M. et al. Superficial bladder tumors. Pathological and clinical review and presentation of a new diagnostic method: fluorescence photodetection of transitional epithelial carcinomas based on protoporphyrin IX induction with delta-aminolevulinic acid (5-ALA) // Rev Med Suisse Romande. – 1995. – Vol. 115, №3. – P. 233–237.
7. Nakayoshi T., Tajiri H., Matsuda K. et al. Magnifying endoscopy combined with narrow band imaging system for early gastric cancer: correlation of vascular pattern with histopathology // Endoscopy. – 2004. – Vol. 36, №12. – P. 1080–1084.
8. Norimura D., Isomoto H., Nakayama T. et al. Magnifying endoscopic observation with narrow band imaging for specialized intestinal metaplasia in Barrett’s esophagus with special reference to light blue crests // Dig Endoscopy. – 2010. – Vol. 22, №2. – P 101–106.
9. Lam S., Kennedy T., Unger M. et al. Localization of bronchial intraepithelial neoplastic lesions by fluorescence bronchoscopy // Chest. – 1998. – Vol. 113, №3. – P. 696–702.
10. Pohl J., May A., Rabenstein T., Pech O. et al. Computed virtual chromoendoscopy: a new tool for enhancing tissue surface structures // Endoscopy. – 2007. – Vol.39. – P. 80–83.
11. Sano Y., Muto M., Tajiri H. et al. Optical/digital chromoendoscopy during colonoscopy using narrow-band imaging system // Dig. Endoscopy. – 2005. – Vol.17. – P. 60–65.
12. Sano Y., Horimatsu T., Fu K.I. et al. Magnifying observation of micro-vascular architecture of colorectal lesions using narrow band imaging system // Dig Endoscopy. – 2006. – Vol.18. – P. 44–51.
13. Tischendorf J.J., Wasmuth H.E., Koch A., Hecker H., Trautwein C., Winograd R. Value of magnifying chromoendoscopy and narrow band imaging (NBI) in classifying colorectal polyps: a prospective controlled study // Endoscopy. – 2007. – 39. – P. 1092–1096.
14. Tung S.Y., Wu C.S., Su M.Y. Magnifying colonoscopy in differentiating neoplastic from nonneoplastic colorectal lesions // Am. J. Gastroenterol. – 2001. – Vol. 96, №9. – P. 2628–2632.
15. Freitag L., Korupp A., Itzigehl I. et al. Experiences with fluorescence diagnosis and photodynamic therapy in a multimodality therapy concept of operated, recurrent bronchial carcinoma // Pneumologie. – 1996. – Vol. 50, № 10. – P. 693–699.
16. Perelman L.Т., Backman V., Wallace M. et al. Observation of periodic fine structure in reflectance from biological tissue: a new technique for measuring nuclear size distribution // Phys. Rev. Lett. – 1998. – Vol. 80. – P. 627–630.
17. Rodriguez J., Yaroslavsky I., Yaroslavsky A. et al. Timeresolved imaging in diffusive media // Handbook of Opt. Biomed. Diagnostics / Ed. V.V. Tuchin. Bellingham: SPIE Press, 2002. – P. 107. – Chap. 6.
18. Wallace M.B., Perelman L.T., Backman V. et al. Endoscopic detection of dysplasia in patients with Barrett’s esophagus using lightscattering spectroscopy // Gastroenterology. – 2000. – Vol. 119, № 3. – P. 677–682.
19. Zagaynova E., Gladkova N., Shakhova N. Endoscopic OCT with forward-looking probe: clinical studies in urology and gastroenterology // J. Biophotonics. – 2008. – Vol. 1, № 2. – P. 114–128.
20. Keller R., Winde G., Terpe HJ, Foerster EC, Domschke W. Fluorescence endoscopy using a fluorescein-labeled monoclonal antibody against carcinoembryonic antigen in patients with colorectal carcinoma and adenoma // Endoscopy. – 2002. – 34. – P. 801–807.
21. McCallum A.L., Jenkins J.T., Gillen D. et al. Evaluation of autofluorescence colonoscopy for the detection and diagnosis of colonic polyps // Gastrointest Endosc. – 2008. – Vol. 68, № 2. – P. 283– 290.
22. DuVall G.A., Kost J., Scheider D. et al. Laser induced fluorescence endoscopy: A pilot study of a real-time autofluorescence imaging system for early detection of dysplasia and carcinoma in the gastrointestinal tract // Endoscopy. – 1996. – № 8. – P. 45.
23. Kriegmair M., Baumgartner R. et al. Early clinical experience with 5-aminolevulinic acid for the photodynamic therapy of superficial bladder cancer // Br. J. Urol. – 1996. – Vol. 77, № 5. – P. 667–671.
24. Kriegmair M., Baumgartner R. Intravesiculaere Instillation von Delta-Aminolaevulinsaere (ALA) Eine neue methode zur photodynamischen Diagnostik und Therapie // Laser-Medizin. – 1994. – № 8. – P. 83.
25. Lam S., Kennedy T., Unger M. et al. Localization of bronchial intraepithelial neoplastic lesions by fluorescence bronchoscopy // Chest. – 1998. – Vol. 113, № 3. – P. 696–702.
26. Rokahr I., Andersson-Engels S. et al. Optical detection of urinary bladder carcinoma utilising tissue autofluorescence and protoporphyrin IX-induced fluorescence following low-dose ALA instillation // SPIE. – 1995. – Vol. 2627-2632. – P. 172–176.
27. Endlicher E., Knuechel R. et al. Endoscopic fluorescence detection of low and high grade dysplasia in Barrett’s oesophagus using systemic or local 5-aminolaevulinic acid sensitisation // Gut. – 2001. – Vol. 48, № 3. – P. 314–319.
Review
For citations:
Razgivina А.А., Nechipai А.М., Volova А.V., Goryaev S.М., Sokolov А.А. Spectrophotometric methods and magnifying endoscopy for differential diagnosis of colon lesions. Photodynamic therapy and photodyagnosis. 2013;2(1):37-41. (In Russ.)
Views:
816
Email this article 