Photodynamic therapy for early cancer of hollow organs
https://doi.org/10.24931/2413-9432-2015-4-1-22-25
Abstract
New medical technology of photodynamic therapy for cancer of hollow organs with photosens determines parameters of irradiation (sites of placement and position of light guide, number of positions and duration of irradiation) to reduce probability of injury during irradiation of intact mucosa in hollow organ due to optimization of light dose. The technology allows to avoid inflammatory and necrotic injury of intact mucosa on the contralateral wall of organ and late complications and to achieve complete tumor regression depending on localization in 73–87% of cases for follow-up period from 1 to 11 years.
About the Authors
E. V. FilonenkoRussian Federation
V. V. Sokolov
Russian Federation
V. D. Menenkov
Russian Federation
G. P. Krylova
Russian Federation
References
1. Luk'yanets E.A. Novye fotosensibilizatory dlya fotodinamicheskoi terapii (New photosensitizers for photodynamic therapy), Rossiiskii khimicheskii zhurnal, 1998, T. XLII, № 5, pp. 9–16.
2. Machinskaya E.A., Ivanova-Radkevich V.I. Obzor mekhanizmov selektivnogo nakopleniya fotosensibilizatorov razlichnoi khimicheskoi struktury v opukholevoi tkani (Review of selective accumulation of photosensitizers with different chemical structure in tumor tissue), Fotodinamicheskaya terapiya i fotodiagnostika, 2013, № 4, pp. 19–23.
3. Juzeniene A. and Moan J. The history of PDT in Norway: рart one – identification of basic mechanisms of general PDT, Photodiag. Photodynam. Ther., 2007, Vol. 4, pp. 3–11.
4. Luk'yanets E.A. Poisk novykh fotosensibilizatorov dlya fotodinamicheskoi terapii (Search for new photosensitizers for photodynamic therapy), Fotodinamicheskaya terapiya i fotodiagnostika, 2013, No. 3, pp. 3–16.
5. Castano A.P. et al. Mechanisms in photodynamic therapy: part one – photosensitizers, photochemistry and cellular localization, Photodiag. Photodynam. Ther., 2004, Vol. 1, pp. 279–293.
6. Moghissi K. and Dixon K. Photodynamic therapy in the management of malignant pleural mesothelioma: a review, Photodiag. Photodynam. Ther., 2005, Vol. 2, pp. 135–147.
7. Moan J. and Peng Q. An outline of the history of PDT, Photodynamic Therapy. Comprehensive series in Photochem. Photobiol. Sci. Ed. T. Patrice. The Royal Society of Chemistry, London, 2003, pp. 3–17.
Review
For citations:
Filonenko E.V., Sokolov V.V., Menenkov V.D., Krylova G.P. Photodynamic therapy for early cancer of hollow organs. Photodynamic therapy and photodyagnosis. 2015;4(1):22-25. (In Russ.) https://doi.org/10.24931/2413-9432-2015-4-1-22-25