Роль трансмембранных переносчиков в накоплении 5-АЛК-индуцированного протопорфирина IX в опухолевых клетках
https://doi.org/10.24931/2413-9432-2024-13-2-43-48
Аннотация
Одной из причин различий в эффективности фотодинамической терапии с применением 5-аминолевулиновой кислоты (5-АЛК) при различных типах злокачественных новообразований могут быть особенности экспрессии в этих тканях мембранных транспортеров, участвующих в переносе самой 5-АЛК в опухолевые и нормальные клетки, а также в выведении из клеток предшественников фотоактивного протопорфирина IX (ППIX) – уро-, копро- и протопорфириногенов. Повышенная экспрессия первых связана с увеличением интенсивности синтеза ППIX. При повышении экспрессии вторых наблюдается снижение скорости синтеза ППIX. В настоящем обзоре описаны основные транспортеры 5-АЛК, уро-, копро- и протопорфириногенов, приведены данные об их экспрессии в различных тканях, обсуждены возможности прогнозирования эффективности фотодинамической терапии с учетом экспрессии указанных транспортеров в злокачественных тканях.
Об авторах
В. И. Иванова-Радкевич
Российский Университет дружбы народов
Россия
Россия
Москва
О. М. Кузнецова
Российский Университет дружбы народов
Россия
Россия
Москва
Е. В. Филоненко
«Московский научно-исследовательский онкологический институт им. П.А. Герцена –
филиал ФГБУ «Национальный медицинский исследовательский центр радиологии» Министерства здравоохранения Российской Федерации
Россия
Россия
Москва
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Рецензия
Для цитирования:
Иванова-Радкевич В.И., Кузнецова О.М., Филоненко Е.В. Роль трансмембранных переносчиков в накоплении 5-АЛК-индуцированного протопорфирина IX в опухолевых клетках. Biomedical Photonics. 2024;13(2):43-48. https://doi.org/10.24931/2413-9432-2024-13-2-43-48
For citation:
Ivanova-Radkevich V.I., Kuznetsova O.M., Filonenko E.V. The role of membrane transport proteins in 5-ALA-induced accumulation of protoporphyrin iX in tumor cells. Biomedical Photonics. 2024;13(2):43-48. https://doi.org/10.24931/2413-9432-2024-13-2-43-48
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