Autofluorescent parameters of the skin changes in accordance of age and insolation

Abstract

There are several key factors, such as age and sun exposure, the effects of which leads to a change in the properties of the skin, detected by the method of autofluorescent dermoscopy. In this paper we used the principle of multispectral imaging of the skin in the light of autofluorescence at excitation wavelength of about 400 nm. It was found that, the background skin glow, the coefficient of heterogeneity and the integral index of autofluorescence significantly increases in a low insolated areas. The most pronounced increase of these parameters observed in the group of women older than 45 years. We can assume that this is due to changes in the properties of collagen and accumulation of advanced glycation end products, and the uneven distribution of absorbent skin chromophores. Insolation accelerates the development of age-related changes of skin AF. According to the literature, in people aged 50–70 years increased NADH (external NADH oxidase) and AGEs compared with age 20–40 years. The differences in the autofluorescence of the skin between high and low insolated sites saved in all age groups. Autofluorescence age-related features described above should be considered for diagnostic and therapeutic measures.