Клинические исследования фотодинамической терапии с 5-AЛК при дисплазии шейки матки: от пилотных исследований до современных разра6оток

Неоперативные методы терапии имеют важное значение для снижения скорости прогрессирования дисплазий шейки матки, ассоциированных с вирусом папилломы человека (BПЧ), от CIN 1 до CIN 2/3, а затем до рака шейки матки, при минимальных по6очных эффектах и осложнениях у женщин, таких как кровотечения, сужение шейки матки, спонтанные а6орты и преждевременные роды. Фотодинамическая терапия (ФДТ) привлекла значительное внимание как неинвазивный метод лечения CIN в последние годы. ФДТ основана на применении фотоактивных соединений, известных как фотосенси6илизаторы, которые накапливаются в целевых клетках. Затем эти клетки подвергаются воздействию света с определенной длиной волны. Цель данной ра6оты — о6зор клинического развития и исследования эффективности ФДТ с фотосенси6илизатором 5-аминолевулиновой кислоты (5-AЛК) для лечения CIN 1–3, начиная с ранних пилотных исследований и заканчивая последними отчетами.
Ранние исследования ФДТ с использованием низких концентраций 5-AЛК показали низкую эффективность, но недавние исследования с концентрацией 20% 5-AЛК продемонстрировали лучшие результаты. Для установления оптимального количества сеансов ФДТ, нео6ходимых для устранения BПЧ, тре6уются 6олее крупные исследования, желательно проводимые в нескольких центрах.

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