Efficiency of photodynamic therapy in the correction of postacne scars and morphofunctional changes in the skin

Abstract

Acne is one of the most common dermatosis in young people. 85% of cases occur in patients between 12 and 24 years old. Duration of the disease, severe form, frequent recurrences of acne, autotraumatization lead to development of symptoms complex postural, manifested in the form of scarring changes, dyschromia, reduced elasticity, increased porosity and mildew. Acne complications occur in 95% of patients. Development of an effective method for the correction of acne complications is a topical problem of modern dermatology and cosmetology. The article describes the method of application of photodynamic therapy with an outer gel photosensitizer based on E6 chloride in patients with severe form of acne after prior treatment with systemic retinoids. The morphofunctional indicators of the skin and the composition of the microbiome in the dynamics were studied. As a result of the course of photodynamic therapy, resolution of scarring was observed in 97,2% of patients, disappearance of pigmentation on cheeks and skin on the forehead in 89,1% and 91,9% of patients respectively, restoration of elasticity in 100% of subjects, decrease in oiliness on the cheeks and skin in 91% and 94,5 % of patients respectively.
The exact exposure of the photosensitizing gel when applied externally to the scar tissue, the time range of its highest concentration and optimal duration of the procedure were determined. As a result of the application of photodynamic therapy, the skin relief was leveled, its oiliness decreased, the pigmentation disappeared and the elasticity was restored. In the microbiota of seborrheic sites, normal flora predominated over pathogenic. This method proved to be effective in the correction of the postural.