PHOTODYNAMIC THERAPY WITH PHOTOSENSITIZER PHOTOLON FOR BASAL CELL CARCINOMA
https://doi.org/10.24931/2413-9432-2017-6-1-12-19
Abstract
The short-term and long-term outcomes of treatment in 130 patients with basal cell carcinoma (T1N0M0, I stage) using photodynamic therapy with photosensitizer photolon based on chlorine e6 are represented in the article. The session of photodynamic therapy was performed 2.5-3 h after intravenous injection of photolon at dose of 2-2.5 mg/kg using semiconductor laser (λ=660±5 nm, laser power density — from 0.1 to 0.52 W/cm2, light dose — from 50 to 300 J/cm2). Complete regression of primary and recurrent carcinomas was observed in 90.9% and 88.9% of patients, respectively. For follow-up period of 3 to 76 months the local recurrence of the tumor was in detected in 6.9% of cases. Patients, who followed the light regimen for 2–3 days after photolon administration avoiding direct sun light exposure, had no manifestation of phototoxicity. Ten patients who failed to follow the light regimen had mild hyperemia, itching and burning in the exposed skin area selflimiting in several hours. Cosmetic results of photodynamic therapy with photolon are superior to those for traditional treatment methods for this disease.
About the Authors
D. A. Tzerkovsky
N.N. Alexandrov National Cancer Centre of Belarus
Belarus
Belarus
A. N. Mazurenko
N.N. Alexandrov National Cancer Centre of Belarus
Belarus
Belarus
N. A. Petrovskaya
N.N. Alexandrov National Cancer Centre of Belarus
Belarus
Belarus
T. P. Artemyeva
N.N. Alexandrov National Cancer Centre of Belarus
Belarus
Belarus
References
1. Gamayunov S.V., Shumskaya I.S. Basal cell skin carcinoma– review of current state of the problem, Prakticheskaya onkologiya, 2012, Vol. 13, No. 2, pp. 92-106. (in Russian).
2. Mohan S.V., Chang A.L. Advanced basal cell carcinoma: epidemiology and therapeutic innovations, Curr. Dermatol. Rep., 2014, Vol. 3, pp. 40-45.
3. Kapinus V.N., Kaplan M.A., Spichenkova I.S., Shubina A.M., Yaroslavtseva-Isaeva E.V. Photodynamic therapy for epithelial malignant neoplasms of skin, Biomedical photonics, 2014, Vol. 3, No. 3, pp. 9-14. (in Russian).
4. Istomin Yu.P., Chalov V.N., Tserkovskii D.A. Photodynamic therapy for basal cell skin carcinoma with medication Photolon, Med. novosti, 2010, No. 10, pp. 86-90. (in Russian).
5. Molochkov V.A., Snarskaya E.S., Polyakov P.Yu., Afonin A.V., Sukhova T.E., Khlebnikova A.N., Taranei T.A., Koroleva T.E., Kladova A.Yu., Chelyukanova M.V., Kozlova E.S. To the problem of basal cell skin carcinoma, Ros. zhurn. kozh. i ven. bol., 2005, No. 6, pp. 4-9. (in Russian).
6. Kutsenok V.V., Gamaleya N.F. Photodynamic therapy for malignant tumors, Onkologiya, 2003, No. 1, pp. 69-72. (in Russian).
7. Zlokachestvennye novoobrazovaniya v Rossii v 2002 godu (zabolevaemost' i smertnost') [Malignant neoplasms in Russia in 2002 (incidence and mortality)], by Chissov V.I. Moscow, MNIOI im. P.A. Gertsena Publ., 2004. 256 p.
8. Griffiths R.W. Audit of histologically incompletely excised basal cell carcinomas: recommendations for management by re-excision, Br. J. Plast. Surg., 1999, Vol. 52, No. 1, pp. 24-28.
9. Ceilley R.I., Del Rosso J.Q. Current modalities and new advances in the treatment of basal cell carcinoma, Int. J. Dermatol., 2006, Vol. 45, No. 5, pp. 489-498.
10. Nayak C.S. Photodynamic therapy in dermatology, Indian. J. Dermatol. Venereol. Leprol., 2005, Vol. 71, pp. 155-160.
11. Stranadko E.F. A historical sketch of the development of photodynamic therapy: Review, Laz. med., 2002, Vol. 6., Is. 1, pp. 4-8. (in Russian).
12. Kelty C.J., Brown N.J., Reed M.W., Ackroyd R. The use of 5-aminolaevulinic acid as a photosensitizer in photodynamic therapy and photodiagnosis, Photochem. Photobiol. Sci., 2002, Vol. 1, pp. 158-168.
13. Swanson E.L., Amdur R.J., Mendenhall W.M., Morris C.G., Kirwan J.M., Flowers F. Radiotherapy for basal cell carcinoma of the medial canthus region, Laryngoscope, 2009, Vol. 119, No. 12, pp. 2366-2368.
14. Rodriguez-Vigil T., Vázquez-López F., Perez-Oliva N. Recurrence rates of primary basal cell carcinoma in facial risk areas treated with curettage and electrodesiccation, J. Am. Acad. Dermatol., 2007, Vol. 56, No. 1, pp. 91-95.
15. Malishevskaya N.P. The case of late diagnosis for primary multiple basal cell skin carcinoma, Ros. zhurn. kozh. i vener. bol., 1998, No. 2, pp. 21-23. (in Russian).
16. Mroz P., Yaroslavsky A., Kharkwal G.B., Hamblin M.R. Cell death pathways in photodynamic therapy of tumors, Cancers, 2011, Vol. 3, pp. 2516-2539.
17. Dougherty T.J., Gomer C.J., Henderson B.W., Jori G., Kessel D., Korbelik M., Moan J., Peng Q. Photodynamic Therapy, J. Nat. Cancer Ins., 1998, Vol. 90, No. 12, pp. 889-905.
18. Agostinis P., Berg K., Cengel K.A., Foster T.H., Girotti A.W., Gollnick S.O., Hahn S.M., Hamblin M.R., Juzeniene A., Kessel D., Korbelik M., Moan J., Mroz P., Nowis D., Piette J., Wilson B.C., Golab J. Photodynamic Therapy of Cancer: An Update, CA Cancer J. Clin., 2011, Vol. 61(4), pp. 250-281.
19. Farhi D., Bedane C., Savary J., Basset-Seguin N. The France-PDT study: a national prospective observational cohort survey on the use of methyl- aminolevulinate photodynamic therapy in France, with up to 6-month follow-up, Eur. J. Dermatol., 2013, Vol. 23, No. 1, pp. 68-76.
20. de Vijlder H.C., Sterenborg H.J., Neumann H.A., Robinson D.J., de Haas E.R. Light fractionation significantly improves the response of superficial basal cell carcinoma to aminolaevulinic acid photodynamic therapy: five-year follow-up of a randomized, prospective trial, Acta Derm.Venereol, 2012, Vol. 92, No. 6, pp. 641-647.
21. Lindberg-Larsen R., Sølvsten H., Kragballe K. Evaluation of recurrence after photodynamic therapy with topical methylaminolaevulinate for 157 basal cell carcinomas in 90 patients, Acta Derm. Venereol., 2012, Vol. 92, No. 2, pp. 144-147.
22. Stranadko E.F., Volgin V.N., Ryabov M.V. Photodynamic therapy for basal cell skin carcinoma with photogem, Klin. dermatol. venerol., 2008, No. 6, pp. 28-33. (in Russian).
23. Filonenko E.V. Physical methods in the treatment of patients with skin cancer, Meditsinskie tekhnologii. Otsenka i vybor, 2012, No. 2(8), pp. 100-105. (in Russian).
24. Volgin V.N., Sokolova T.V., Kolbina M.S. Photodynamic therapy with application form of fotoditazin in the patient with multiple basal cell carcinoma, Klin. dermatol. venerol., 2011, No. 1, pp. 72-76. (in Russian).
25. Stranadko E.F., Volgin V.N., Lamotkin I.A., Ryabov M.V., Sadovskaya M.V. Photodynamic therapy for basal cell skin carcinoma with photosensitizer fotoditazin, Ros. bioter. zhurn., 2008, Vol. 7, No. 4, pp. 7-11. (in Russian).
26. Kochneva E.V., Privalov V.A., Lappa A.V. Results of phase II clinical trial of the photosensitizer of II generation «Radachlorin» solution for intravenous injection 0,35% in patients with basal cell skin carcinoma, Izv. Chelyab. nauchn. tsentra, 2004, Is. 2, No. 23, pp. 167-171. (in Russian).
27. Tsyb A.F., Kaplan M.A., Romanko Yu.S., Popuchiev V.V. Klinicheskie aspekty fotodinamicheskoi terapii [Klinical aspects of photodynamic therapy]. Kaluga, Izdatel'stvo nauchnoi literatury N.F. Bochkarevoi Publ., 2009, pp. 50-68.
28. Kaplan M.A., Kapinus V.N., Popuchiev V.V., Yaroslavtseva-Isaeva E.V., Spichenkova I.S., Shubina A.M., Borgul' O.V., Goranskaya E.V. Photodynamic therapy: results and opportunities, Radiatsiya i risk, 2013, Vol. 22, No. 3, pp. 115-123. (in Russian).
29. Taranets T.A., Sukhova T.E., Romanko Yu.S. Photodynamic therapy for basal cell skin carcinoma with local and intravenous administration of chlorine photosensitizer «Fotolon», Al'manakh klin. med., 2007, No. 15, pp. 283-287. (in Russian).
Review
For citations:
Tzerkovsky D.A., Mazurenko A.N., Petrovskaya N.A., Artemyeva T.P. PHOTODYNAMIC THERAPY WITH PHOTOSENSITIZER PHOTOLON FOR BASAL CELL CARCINOMA. Biomedical Photonics. 2017;6(1):12-19. (In Russ.) https://doi.org/10.24931/2413-9432-2017-6-1-12-19
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