Influence of the carbohydrate fragment position in the macrocycle of chlorine e6 trimethyl ester glycosylated derivatives on their in vitro photo- induced activity
Abstract
The physicochemical and photophysical properties, as well as photo-induced activity, of glycoconjugates based on chlorine е6 trimethyl ether with various positions of carbohydrate fragment in the macrocycle have been studied. The photo-induced activity was investigated in the human (HEp2, A549 and HT29) and animal (LLC) cell lines. The tested compounds showed in vitro both high photo-induced activity and high stability in the dark. The photosensitizer with galactose in the A pirrole ring demonstrated the highest activity (the half maximal inhibitory concentration (ИК50) varied from 27±2 nM to 75±5 nM in tests on different cell lines). Dyes with sugar substitutes in the C pirrole ring were 5–10 times less active.
About the Authors
R. I. Yakubovskaya
P.A.Herzen Moscow Cancer Research Institute, Moscow
Russian Federation
Russian Federation
A. D. Plyutinskaya
P.A.Herzen Moscow Cancer Research Institute, Moscow
Russian Federation
Russian Federation
E. A. Plotnikova
P.A.Herzen Moscow Cancer Research Institute, Moscow
Russian Federation
Russian Federation
M. A. Grin
Lomonosov Moscow State University of Fine Chemical Technologies, Moscow
Russian Federation
Russian Federation
A. F. Mironov
Lomonosov Moscow State University of Fine Chemical Technologies, Moscow
Russian Federation
Russian Federation
V. S. Sergeeva
N.I. Pirogov Russian State Medical University, Moscow
Russian Federation
Russian Federation
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Review
For citations:
Yakubovskaya R.I., Plyutinskaya A.D., Plotnikova E.A., Grin M.A., Mironov A.F., Sergeeva V.S. Influence of the carbohydrate fragment position in the macrocycle of chlorine e6 trimethyl ester glycosylated derivatives on their in vitro photo- induced activity. Photodynamic therapy and photodyagnosis. 2014;3(2):3-7. (In Russ.)
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