Photodynamic therapy for cervical lesions
Abstract
The experience of treatment for precancer and early cervical cancer by photodynamic therapy in 12 patients with primary diagnosis H-SIL (CIN II–III) and cancer in situ is described. Chlo-rine photosensitizer Photolon was given intravenously at a dose of 0.75–1.15 mg/kg body weight. 2.5 h later the treatment with polyposition laser exposure (light dose – 150 J/cm2, light power density – 400–500 mW/cm2) was made. Thirty days later conization of the cervix with endocervical curettage assessing therapeutic response of cervical tumor tissue was per-formed. According to histological data complete response was in 4 patients, minute foci of CIN I were determined in 7 patients, 1 patient had foci of CIN II. 8 of 10 HPV-positive patients had complete eradication of HPV after treatment. There were no serious adverse events after light exposure. Marked therapeutic response, high anti-viral activity and good feasibility allow to consider photodynamic therapy as alternative organ-sparing treatment of early cancer and pre-cancer of cervix.
About the Authors
E. V. GrebenkinaRussian Federation
S. V. Gamajunov
Russian Federation
S. S. Kuznetsov
Russian Federation
O. V. Onoprienko
Russian Federation
N. A. Illarionova
Russian Federation
N. M. Shakhova
Russian Federation
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Review
For citations:
Grebenkina E.V., Gamajunov S.V., Kuznetsov S.S., Onoprienko O.V., Illarionova N.A., Shakhova N.M. Photodynamic therapy for cervical lesions. Photodynamic therapy and photodyagnosis. 2014;3(2):12-14. (In Russ.)