Сонодинамическая терапия с фотосенсибилизаторами и ее комбинация с фотодинамической терапией в лечении злокачественных опухолей
Аннотация
В обзоре подробно освещены механизмы, лежащие в основе применения сонодинамической терапии с фотосенсибилизаторами (ультразвук + фотосенсибилизатор), а также комбинации сонодинамической и фотодинамической терапии (ультразвук + фотосенсибилизатор + световое воздействие) для лечения злокачественных новообразований. Приведены и проанализированы данные по эффективности применения указанных методов с фотосенсибилизаторами различной химической структуры в экспериментальных исследованиях в системах in vitro и in vivo на различных опухолевых моделях, а также в клинических исследованиях.
Об авторах
Д. А. Церковский
Республиканский научно-практический центр онкологии и медицинской радиологии им. Н.Н. Александрова, Лесной, Республика Беларусь
Беларусь
Беларусь
Е. Н. Александрова
Республиканский научно-практический центр онкологии и медицинской радиологии им. Н.Н. Александрова, Лесной, Республика Беларусь
Беларусь
Беларусь
Т. П. Лапцевич
Республиканский научно-практический центр онкологии и медицинской радиологии им. Н.Н. Александрова, Лесной, Республика Беларусь
Беларусь
Беларусь
Ю. П. Истомин
Республиканский научно-практический центр онкологии и медицинской радиологии им. Н.Н. Александрова, Лесной, Республика Беларусь
Беларусь
Беларусь
Список литературы
1. Ультразвук в терапии злокачественных опухолей / Под ред. К.П. Балицкого. – Киев: Наукова думка, 1977 – 157 с.
2. Kremkau F.W. Cancer therapy with ultrasound: A historical review // J. Clin. Ultrasound . – 1979. – Vol. 7. – P. 287–300.
3. Rosenthal I., Sostaric J. Z., Riesz P. Sonodynamic therapy – a review of the synergistic effects of drugs and ultrasound // Ultrasonics Sonochem. – 2004. – Vol. 11(3). – P. 349–363.
4. Lagneaux L. Ultrasonic low–energy treatment: A novel approach to induce apoptosis in human leukemic cells // Exp. Hematol. – 2002. – Vol. 30, Issue 11. – P. 1293–1301.
5. Ashush H. et al. Apoptosis induction of human myeloid leukemic cells by ultrasound exposure // Cancer Res. – 2000 – Vol. 60. – P. 1014–1020.
6. Сергеева Н.С. и др. Влияние различных режимов низкочастотного ультразвука на выживаемость опухолевых клеток человека in vitro // Бюлл. экспер. биол. мед. – 2001. – Т.131, № 3. – С. 331–334.
7. Бирюков Ю.В. О влиянии ультразвука низкой частоты на клетки опухоли в эксперименте // Груд. хирургия. – 1989. – № 3 – С. 64–69.
8. Kaufman G. E. et al. Lysis and viability of cultured mammalian cells exposed to 1 MHz ultrasound // Ultrasound Med. Biol. – 1977. – Vol. 3, Issue 1. – P. 21–25.
9. Hrazdira I., Skorpıkova J., Dolnıkova M. Ultrasonically induced alterations of cultured tumour cells // Eur. J. Ultrasound. – 1998. – Vol. 8. – P. 43–49.
10. Fang H. Y. et al. The effects of power on–off durations of pulsed ultrasound on the destruction of cancer cells // Int. J. Hyperthermia. – 2007 – Vol. 23, No 4. – P. 371–380.
11. Dai S., Hu S., Wu C. Apoptotic effect of sonodynamic therapy mediated by hematoporphyrin monomethyl ether on C6 glioma cells in vitro // Acta Neurochir. – 2009. – Vol. 151. – P. 1655–1661.
12. Андронова Н. В. и др. Комбинированная терапия злокачественных опухолей с использованием локального ультразвукового воздействия (экспериментальное исследование) // Рос. биотерап. ж. – 2005. – Т. 4, № 3. – С.103–107.
13. Nonaka M. et al. Sonodynamic therapy consisting of focused ultrasound and a photosensitizer causes a selective antitumor effect in a rat intracranial glioma model // Anticancer Res. – 2009. – Vol. 29, No.3. – P. 943–950.
14. Wood A.K.W. et al. The antivascular action of physiotherapy ultrasound on murine tumors // Ultrasound Med Biol. – 2005. – Vol. 31, No 10. – P. 1403–1410.
15. Martins B. I. et al. Survival of cultured mammalian cells exposed to ultrasound // Rad. Environm. Biophys. – 1977. – Vol. 14. – P. 243–250.
16. Kobayashi H., Sakuma S. Treatment of human superficial tumors by ionizing radiation combined with ultrasound // Nippon Igaku Hoshasen Gakkai Zasshi. – 1991. – Vol. 51, No 2. – P. 149–154.
17. N. Yumita et al. Hematoporphyrin as a sensitizer of cell damaging effect of ultrasound // Jpn. J. Cancer Res. – 1989. – Vol. 80. – P. 219–222.
18. Kessel D., Porphyrin–induced enhancement of ultrasound cytotoxicity // Int. J. Radiat. Biol. – 1994. – Vol. 66, No 2. – P. 221–228.
19. Заболотный Д.И., Пухлик С.М., Пионтковская М.Б. Новые возможности применения сонодинамической терапии в онкоринологии // Вестник оториноларингологии. – 2006. – № 3. – С. 23–26.
20. Hiraoka W. et al. Comparison between sonodynamic effect and photodynamic effect with photosensitizers on free radical formation and cell killing // Ultrasonics Sonochemistry – 2006. – Vol. 13. – P. 535–542.
21. Yumita N. et al. Sonodynamically–induced apoptosis, necrosis, and active oxygen generation by mono–l–aspartyl chlorin e6 // Cancer Sci. – 2008. – Vol. 99, No 1. – P. 166–172.
22. Umemura S. et al. Sonodynamically induced effect of rose bengal on isolated sarcoma 180 cells // Cancer Chemother/ Pharmacol. – 1999. – Vol. 43, No 5. – P. 389–393.
23. He Y. et al. 5-Aminolaevulinic acid enhances ultrasound-induced mitochondrial damage in K562 cells // Ultrasonics. – 2010. – Vol. 50. – P. 777–781.
24. Zheng R. et al. The sonodynamic effects of chlorin e6 on the proliferation of human lung adenocarcinoma cell SPCA–1 // Chin. J. Lung Cancer. – 2010. – Vol. 13, No 3. – P. 201–205.
25. Tserkovsky D.A., Alexandrova E.N., IstominY.P. Photolon enhancement of ultrasound cytotoxicity // Exp. Oncol. – 2011. – Vol. 33, No 2. – P. 107–109.
26. Umemura S.I., Yumita N., Nishigaki R. Enhancement of ultrasonically induced cell-damage by a gallium-porphyrin complex ATX-70 // Jpn. J. Cancer Res. – 1993. – Vol. 84. – P. 582.
27. Yumita N., Han Q.S., Umemura S. Sonodynamically induced apoptosis with porfimer sodium in HL–60 cells // Anticancer Drugs. – 2007. – Vol. 18, No 10. – P. 1149–1156.
28. Li J. et al. In vitro study of hematoporphyrin monomethyl ether– mediated sonodynamic effects on C6 glioma cells / // Neurol. Sci. – 2008 – Vol. 29. – P. 229–235.
29. Wang P. et al. Comparison between sonodynamic effects with protoporphyrin IX and hematoporphyrin on the сytoskeleton of Ehrlich ascites carcinoma cells // Cancer Biother. Radiopharm. – 2010. – Vol. 25, No 1. – P. 55–64.
30. Tachibana K. et al. Enhancement of cell killing of HL-60 cells by ultrasound in the presence of the photosensitizing drug Photofrin II // Cancer Letters. – 1993. – Vol. 72, No 3. – P. 195–199.
31. Umemura K. et al. Sonodynamically induced antitumor effect of pheophorbide a / // Cancer Lett. – 1996. – Vol. 102, No 1–2. – P. 151–157.
32. Liu Q. et al. Sonodynamic effects of protoporphyrin IX disodium salt on isolated sarcoma 180 cells // Ultrasonics. – 2006. – Vol. 45, No 1–4. – P. 56–60.
33. Mi N. et al. Induction of sonodynamic effect with protopophyrin IX on isolate hepatoma 22 cells // Ultrasound Med. Biol. – 2009. – Vol. 35, No 4. – P. 680–686.
34. Wang X.B. et al. Study of cell killing effect on S180 by ultrasound activating protoporphyrin IX // Ultrasonics. – 2008. – Vol. 48, No 2. – P. 135–140.
35. Miyoshi N., Misik V., Riesz P. Sonodynamic toxicity of gallium–porphyrin analogue ATX–70 in human leukemia cells // Radiat. Res. – 1997. – Vol. 148, No 1. – P. 43–47.
36. Yumita N. et al. Sonodynamically induced antitumor effect of 4–formyloximethylidene–3–hydroxy–2–vinyl–deuterio–porphynyl(IX)–6,7–dia spartic acid (ATX–S10) // Jpn. J. Cancer Res. – 2000. – Vol. 91, No 2. – P. 255–260.
37. Xu J. et al. Sonodynamic action of pyropheophorbide–a methyl esther in liver cancer cells // J. Ultrasound Med. – 2010. – Vol. 29, No 7. – P. 1031–1037.
38. Chen Z. et al. Use of a novel sonosensitizer in sonodynamic therapy of U251 glioma cells in vitro // Exp. Ther. Med. – 2012. – Vol. 3, No 2. – P. 273–278.
39. Yumita N., Nishigaki T., Umemura K. Synergetic effect of ultrasound and hematoporphyrin on sarcoma 180 // J. Jpn. Cancer. Res. – Vol. 81. – 1990. – P. 304.
40. Yumita N., Sasaki K., Umemura S., Yukawa A. Sonodynamically induced antitumor effect of gallium–porphyrin complex by focused ultrasound on experimental kidney tumor // Cancer Lett. – 1997. – Vol. 112, No 1. – P. 79–86.
41. Yumita N., Umemura S. Sonodynamic therapy with photofrin II on AH130 solid tumor. Pharmacokinetics, tissue distribution and sonodynamic antitumoral efficacy of photofrin II // Cancer Chemother. Pharmacol. – 2003. – Vol. 51, No. 2. – P. 174–178.
42. Yumita N., Umemura S. Sonodynamic antitumour effect of chloroaluminum phthalocyanine tetrasulfonate on murine solid tumour // J. Pharm. Pharmacol. –2004. – Vol. 56, No. 1. – P. 85–90.
43. Yumita N. Sonodynamic therapy on chemically induced mammary tumor: pharmacokinetics, tissue distribution and sonodynamically induced antitumor effect of gallium–porphyrin complex ATX–70 // Cancer Chemother. Pharmacol. – 2007. – Vol. 60. – P. 891–897.
44. Liu Q. et al. Comparison between sonodynamic effect with protoporphyrin IX and hematoporphyrin on sarcoma 180 // Cancer Chemother Pharmacol. – 2007. – Vol. 60, No 5. – P. 671–680.
45. Wang X., Lewis T., Mitchell D. The tumoricidal effect of sonodynamic therapy (SDT) on S–180 sarcoma in mice // Integr. Cancer Ther. – 2008. – Vol. 7. – P. 96–102.
46. Wang X. et al. Sonodynamically induced anti–tumor effect with protoporphyrin IX on hepatoma–22 solid tumor // Ultrasonics. – 2011. – Vol. 51, No 5. – P. 539–546.
47. Sazgarnia A. et al. A novel nanosonosensitizer for sonodynamic therapy: in vivo study on a colon tumor model // J. Ultrasound Med. – 2011. – Vol. 30, No 10. – P. 1321–1329.
48. Alamolhoda M. et al. Comparing the in vivo sonodynamic effects of dual– and single–frequency ultrasound in breast adenocarcinoma // Journal of Medical Ultrasonics. – 2012. – Vol. 39, No 3. – P. 115–125.
49. Barati A.H., Mokhtari–Dizaji M. Ultrasound dose fractionation in sonodynamic therapy // Ultrasound Med. Biol. – 2010. – Vol. 36, No 6. – P. 880–887.
50. Shi H. et al. Pharmacokinetic study of a novel sonosensitizer chlorin–e6 and its sonodynamic anti–cancer activity in hepatoma–22 tumor–bearing mice // Biopharm. Drug Dispos. – 2011. – Vol. 32, No 6. – P. 319–332.
51. Chen B. et al. The tumor affinity of chlorin e6 and its sonodynamic effects on non–small cell lung cancer // Ultrason. Sonochem. – 2013. – Vol. 20, No 2. – P. 667–673.
52. Nonaka M. et al. Sonodynamic therapy consisting of focused ultrasound and a photosensitizer causes a selective antitumor effect in a rat intracranial glioma model // Anticancer Res. – 2009. – Vol. 29, No 3. – P. 943–950.
53. Ohmura T. et al. Sonodynamic therapy with 5–aminolevulinic acid and focused ultrasound for deep–seated intracranial glioma in rat // Anticancer Res. – 2011. – Vol. 31, No 7. – P. 2527–2533.
54. Jeong E.G. et al. Sonodynamically induced antitumor effects of 5-aminolevulinic Acid and fractionated ultrasound irradiation in an orthotopic rat glioma model // Ultrasound Med Biol. – 2012. – Vol. 38, No 12. – P. 2143–2150.
55. Заболотный Д.И., Пухлик С.М., Пионтковская М.Б. Новые возможности применения сонодинамической терапии в онкоринологии // Вестник оториноларингологии. – 2006. – № 3. – С. 23–26.
56. Kessel D. Modes of photodynamic vs. sonodynamic cytotoxicity // J. Photochem. Photobiol. – 1995. – Vol. 28. – P. 219–221.
57. Jin Z.H. Combination effect jf photodynamic and sonodynamic therapy on experimental skin squamous cell carcinoma in C3H/ HeN mice // J. Dermatol. – 2000. – Vol. 27. – P. 294–306.
58. Nomikou N. et al. The effects of ultrasound and light on indocyanine-green-treated tumour cells and tissues // Chem. Med Chem. – 2012. – Vol. 7, No 8. – P. 1465–1471.
59. Bakhshizadeh M. et al. Effects of Combined Sonodynamic and Photodynamic Therapies on a Colon Carcinoma Tumor Model // Iran J Basic Med Sci – 2011. – Vol. 14, No 3. – P. 205–212.
60. Tserkovsky D.A. et al. Effects of combined sonodynamic and photodynamic therapies with photolon on a glioma C6 tumor model // Exp Oncol. – 2012. – Vol. 34, No 4. – P. 332–335.
61. Wang, X., Mitchell D., Lewis T. J. Primary clinical use of sonodynamic therapy (SDT) for advanced breast cancer // Journal of Clinical Oncology. – 2008. – Vol. 26, No 15. – P. 12–29.
62. Wang X. et al. Sonodynamic and photodynamic therapy in advanced refractory breast cancer // Journal of Clinical Oncology. – 2012. – Vol. 30, No 27, suppl. – P. 118.
63. Kenyon, J.N., Fulle R.J., Lewis T.J. Activated Cancer Therapy Using Light and Ultrasound – A Case Series of Sonodynamic Photodynamic Therapy in 115 Patients Over a 4 Year Period // Current Drug Therapy. – 2009. – Vol. 4. – P. 179–193.
Рецензия
Для цитирования:
Церковский Д.А., Александрова Е.Н., Лапцевич Т.П., Истомин Ю.П. Сонодинамическая терапия с фотосенсибилизаторами и ее комбинация с фотодинамической терапией в лечении злокачественных опухолей. Фотодинамическая терапия и фотодиагностика. 2014;3(2):18-23.
For citation:
Zerkovskiy D.A., Alexandrova E.N., Laptsevich T.P., Istomin J.P. Sonodynamic therapy with photosensitizers and its combination with photodynamic therapy in treatment of malignant tumors. Photodynamic therapy and photodyagnosis. 2014;3(2):18-23. (In Russ.)
Просмотров: 1116
Послать статью по эл. почте 