Photodynamic therapy of psoriasis
https://doi.org/10.24931/2413-9432-2023-12-1-28-36.
Abstract
Photodynamic therapy (PDT) in the treatment of psoriasis remains the subject of much debate. There is no consensus in the scientific community about effective and safe PDT regimens for psoriasis. Described in the published materials doses and concentrations of photosensitizers for psoriasis, as well as light doses, differ by dozens of times. The purpose of this review is to analyze the efficacy and safety profile of various PDT regimens for psoriasis. Some studies demonstrate 100% effectiveness of the method in certain modes (complete or partial clearance of psoriasis foci after PDT). In particular, such efficiency was obtained with the application of 20% 5-ALA (light dose 15 J/cm2) and 0.1% methylene blue (light dose 15 J/ cm2). The main factor limiting the use of PDT in psoriasis, and in some cases even being the reason for treatment interruption, is severe pain during the irradiation procedure. This requires careful development of PDT regimens in patients with psoriasis.
About the Authors
E. V. Filonenko
P.A. Herzen Moscow Oncology Research Center – branch of FSBI NMRRC of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Moscow
V. Ivanova-Radkevich
Peoples’ Friendship University of Russia (RUDN University)
Russian Federation
Russian Federation
Moscow
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For citations:
Filonenko E.V., Ivanova-Radkevich V. Photodynamic therapy of psoriasis. Biomedical Photonics. 2023;12(1):28-36. https://doi.org/10.24931/2413-9432-2023-12-1-28-36.
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