Photodynamic therapy with photosensitizer photolon for oral leukoplakia
https://doi.org/10.24931/2413-9432-2016-5-2-13-20
Abstract
The objective – to assess tolerability, safety and immediate results of treatment of patients with oral leukoplakia using photodynamic therapy (PDT) with a photosensitizer photolon. The study included 40 patients (7 men, 33 women) with morphologically verified leukoplakia of the oral mucosa. The average age – 55±14 years. Number of treated foci – 109 (1 to 8). Photolon was administered intravenously at doses of 1.7-2.5 mg/kg. Photoirradiation («UPL PDT», Belarus, λ = 660±5 nm) was performed 2.5-3 h after administration: light exposure dose varied from 25 to 100 J/cm2, power density of 0.07 to 0.32 W/cm2, the duration of one field photoirradiation – from 2 to 13.5 min and according to its linear dimensions. The effectiveness of treatment was assessed 1-2 months after PDT by clinical data. Complete regression of foci recorded in 95% of cases (n=38), partial – in 5% (n=2).The follow-up period varied from 1 to 30 months. Full-epithelialization of the wound defect occurred within the period of 3-6 weeks after treatment. Photodynamic therapy may be recommended for patients with circumscribed or widespread oral leukoplakia as a simple, well-tolerated and effective option. Keywords: photodynamic therapy, photolon, oral leukoplakia.
About the Authors
Yu. P. Istomin
N.N. Alexandrov National Cancer Centre of Belarus
Belarus
Lesnoy
Belarus
Lesnoy
T. P. Artemyeva
N.N. Alexandrov National Cancer Centre of Belarus
Belarus
Lesnoy
Belarus
Lesnoy
D. A. Tzerkovsky
N.N. Alexandrov National Cancer Centre of Belarus
Belarus
Lesnoy
Belarus
Lesnoy
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For citations:
Istomin Yu.P., Artemyeva T.P., Tzerkovsky D.A. Photodynamic therapy with photosensitizer photolon for oral leukoplakia. Biomedical Photonics. 2016;5(2):13-20. https://doi.org/10.24931/2413-9432-2016-5-2-13-20
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